Adrenocorticotropin. 48. Synthesis and Biological Activity of [15,16‐d‐lysine,17,18‐d‐arginine] ‐adrenocorticotropin‐(1–19) and an All‐d‐retropeptide Related to the Amino Terminal Octadecapeptide of Adrenocorticotropin*

The peptide [15, 16-D-lysine, 17, 18-D-arginine]-adrenocorticotropin-(1-19) and an all-D-retropeptide related to the amino terminal octadecapeptide of adrenocorticotropin have been synthesized by the solid-phase method. The nonadecapeptide was shown to possess 10-15% of the steroidogenic activity and 3% of the lipolytic activity of adrenocorticotropin-(1-19). The all-D-retropeptide showed no activity and exhibited no inhibitory activity in steroidogenesis and lipolysis.