January 1, 1993IEEE Transactions on Biomedical Engineering

Mechanoelectrical feedback in cardiac myocytes from stretch-activated ion channels

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Population

Cardiac myocytes from neonatal rats

Design

Preclinical

Authors

MAMetin AkayUniversity of Houston WCWilliam CraeliusRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Hypothesis-generating for stretch as an arrhythmia trigger in myocytes; leaves open relevance to intact hearts or clinical arrhythmogenesis.

Structured PICO

Population

Cardiac myocytes from neonatal rats

Intervention

Stretch of membrane patches by suction in the recording pipette

Outcome

Triggering of action potentials (recorded as action currents) and temporal correlation between stretch-activated ion channel (SAC) open probability and action currentssurrogate

Mechanical stretch of cardiac myocytes activates stretch-activated ion channels, injecting sufficient charge to trigger action potentials, supporting the hypothesis that passive mechanical stretch can be arrhythmogenic.

Cite This Study

Akay et al. (1993) studied this question.

synapsesocial.com/papers/6a70127eac440176ef28b845 https://doi.org/10.1109/10.238466

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Bookmark

Implication

Hypothesis-generating for stretch as an arrhythmia trigger in myocytes; leaves open relevance to intact hearts or clinical arrhythmogenesis.

Mechanoelectrical feedback in cardiac myocytes from stretch-activated ion channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanoelectrical feedback in cardiac myocytes from stretch-activated ion channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider