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Repeated injections of tuberculin-active peptide without toxicity prevented cavity formation in rabbit lungs that had been injected with heat-killed tubercle bacilli. This desensitization procedure also suppressed the delayed type skin reaction and the in vitro migration inhibition of alveolar cells with tuberculins, but it had no significant influence upon the passive hemagglutination titer of antipolysaccharide antibody. The correlation between cavity formation and delayed hypersensitivity is discussed.
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Yamamura et al. (1974) studied this question.