What question did this study set out to answer?

The aim is to assess the validity of assays for low molecular weight heparins (LMWH) against the International Standard (IS).

Standardization of Low Molecular Weight Heparins : A Collaborative Study

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The aim is to assess the validity of assays for low molecular weight heparins (LMWH) against the International Standard (IS).
Eight laboratories assayed eight LMW heparins using APTT and three types of anti-Xa methods.
Each method was tested against the International Standard for heparin.
LMW heparins cannot be validly assayed against the IS by APTT or anti-Xa methods.
Potencies varied significantly between assay methods and laboratories.
Adopting a single LMW heparin standard could reduce inter-laboratory variation and method differences.

Population

Eight laboratories assaying eight low molecular weight (LMW) heparins

Intervention

Assay using APTT and three types of anti-Xa methods

Comparator

International Standard (IS) for heparin

Outcome

Validity and inter-laboratory variation of assay methodssurrogate

Adoption of a single LMW heparin standard and a specific assay method is needed to improve validity and reduce inter-laboratory variation.

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LMWH potency assays lack validity and consistency across methods and labs; leaves open whether a dedicated standard can standardize measurements.

Barrowcliffe et al. (1985) studied this question.

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LMWH potency assays lack validity and consistency across methods and labs; leaves open whether a dedicated standard can standardize measurements.