January 1, 1996Biochemical JournalOpen Access

A new inositol 1,4,5-trisphosphate binding protein similar to phospholipase C-δ1

View Full Paper

Ask AI

Bookmark

Population

Rat brain and COS-1 cells

Design

Preclinical

Authors

Discussion

May modulate IP3 signaling in cardiomyocytes; leaves open its role in cardiac calcium handling pending functional studies.

Population

Rat brain and COS-1 cells

Intervention

Isolation and expression of full-length cDNA for the 130 kDa Ins(1,4,5)P3 binding protein

Outcome

Sequence homology, domain structure, PLC activity, and Ins(1,4,5)P3 binding

Identifies a novel 130 kDa Ins(1,4,5)P3 binding protein that is structurally homologous to PLC-delta 1 but lacks catalytic activity.

Kanematsu et al. (1996) studied this question.

View Full Paper

Ask AI

Bookmark