January 1, 1986CRC Critical Reviews in Clinical Laboratory Sciences
Clinical Efficacy of Heparin Fractions: Issues and Answers
Why the study?
Do heparin fractions and fragments provide effective antithrombotic activity with reduced hemorrhage or thrombocytopenia risk compared to standard heparin in patients with thrombotic disorders?
Population
Patients with thrombotic disorders, heparin allergy, or heparin-induced thrombocytopenia
Comparison
Heparin fractions, fragments, and heparinoids vs Unfractionated heparin (standard heparin)
Design
Review
Authors
Discussion
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Member takes
Implication
LMWH may benefit HIT patients; leaves open hemorrhage risks pending prospective human trials.
Structured PICO
Do heparin fractions and fragments provide effective antithrombotic activity with reduced hemorrhage or thrombocytopenia risk compared to standard heparin in patients with thrombotic disorders?
P
Population
Patients with thrombotic disorders, heparin allergy, or heparin-induced thrombocytopenia
I
Intervention
Heparin fractions, fragments, and heparinoids (including low molecular weight heparins and pentasaccharide)
C
Comparator
Unfractionated heparin (standard heparin)
Heparin fractions and low molecular weight fragments offer promising alternatives to unfractionated heparin, particularly for patients with heparin-induced thrombocytopenia or those requiring prolonged anticoagulation.
Cite This Study
Messmore et al. (1986) studied this question.