Why the study?
What is the variability of plasma heparin levels after a standard 5000 iu subcutaneous dose in patients awaiting total hip replacement?
Population
43 patients awaiting total hip replacement
Design
Cohort
Follow-up
8 hours
Authors
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Variable heparin levels after fixed dosing without predictors support considering monitoring; leaves open whether titration improves VTE prevention in hip replacement.
What is the variability of plasma heparin levels after a standard 5000 iu subcutaneous dose in patients awaiting total hip replacement?
Standard low-dose subcutaneous heparin results in variable plasma levels, suggesting individualized monitoring may be necessary to optimize efficacy and safety.
Brozović et al. (1975) studied this question.
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