Key result
Green tea catechins inhibit influenza A RNA polymerase endonuclease activity via galloyl-mediated active site binding.
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The influenza A RNA polymerase possesses endonuclease activity to digest the host mRNA. Thus this endonuclease domain can be a target of anti-influenza A virus drug. Here we report that green tea catechins inhibit this viral endonuclease activity and that their galloyl group is important for their function. Docking simulations revealed that catechins with galloyl group fit well into the active pocket of the endonuclease domain to enable stable binding. Our results provide useful data that make it possible to refine and optimize catechin-based drug design more readily for stability.
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Kuzuhara et al. (2009) studied Influenza A. Green tea catechins was evaluated on Viral endonuclease activity. Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase, and docking simulations indicate the galloyl group fits well into the active pocket to enable stable binding.
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