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September 18, 2001Proceedings of the National Academy of SciencesOpen Access

X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs

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Population

Avian H5 and swine H9 influenza hemagglutinins from viruses closely related to those that caused outbreaks…

Design

Preclinical

Authors

YHYa HaNew Generation University CollegeDSDavid StevensFlinders UniversityJSJ.J. SkehelUniversité Paris-Sud

Discussion

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Implication

Animal data on HA conformations should not guide clinical decisions; leaves open receptor specificity mechanisms for human validation.

Structured PICO

P
Population
Avian H5 and swine H9 influenza hemagglutinins (HAs) from viruses closely related to those that caused outbreaks of human disease in Hong Kong in 1997 and 1999, bound to avian and human cell receptor analogs
I
Intervention
X-ray crystallography structural analysis
O
Outcome
Three-dimensional structures of HA binding sites and atomic contacts at the glycosidic linkage

The study reveals the structural basis for how avian and human influenza receptors are distinguished by hemagglutinins, providing insight into viral adaptation to humans.

Cite This Study

Ha et al. (2001) studied this question.

synapsesocial.com/papers/6a7016ba75498292b70975afhttps://doi.org/10.1073/pnas.201401198
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early Alterations of the Receptor-Binding Properties of H1, H2, and H3 Avian Influenza Virus Hemagglutinins after Their Introduction into Mammals2000 · 874 citations
  2. 2Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness1998 · 1,366 citations
  3. 3The Surface Glycoproteins of H5 Influenza Viruses Isolated from Humans, Chickens, and Wild Aquatic Birds Have Distinguishable Properties1999 · 610 citations
  4. 4Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential1998 · 1,041 citations
  5. 5Origin and evolution of the 1918 “Spanish” influenza virus hemagglutinin gene1999 · 611 citations