Why the study?
While platelet participation in atherothrombosis in acute cardiovascular disease is well studied, their significance in atherosclerosis pathogenesis from the earliest stages requires further study.
Key points are not available for this paper at this time.
Design
Review article
Platelet contributions to early atherosclerosis need clarification; leaves open targeted mechanistic studies before any clinical translation.
The participation of platelets in the development of atherothrombosis in acute forms of cardiovascular diseases is generally recognized and well studied, while their significance in the pathogenesis of vascular atherosclerosis, starting from the earliest stages, requires further study. This article analyzes the role of platelets in the pathogenesis of atherosclerosis. Modern views on the pathogenesis of atherosclerosis, platelet-endothelial interactions, molecular mechanisms of platelet activation, platelet immune function from the point of view of the initial stages of atherogenesis, studies of the effect of antiplatelet therapy in primary and secondary prevention of atherosclerosis are considered. The leading role of platelets in the inflammatory and immune reactions of the human body is indicated, which is realized due to a complex of immune receptors, adhesion molecules and mediators.
No takes yet. Share an insight, caveat, or question.
T. O. Nikolaeva (2021) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: