September 12, 2012Clinical Science

The ACE2 gene: its potential as a functional candidate for cardiovascular disease

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Why the study?

Is ACE2 gene variation associated with cardiovascular disease?

Population

Patients with cardiovascular disease, including hypertension, left ventricular hypertrophy, and coronary…

Design

Review

Authors

LBLouise M. BurrellHeart Failure & Transplant SHStephen HarrapPreventive Cardiology EVElena VelkoskaCSL (Australia)

Discussion

Member takes

Implication

Inconsistent ACE2 associations preclude clinical genotyping in CVD; leaves open causal links pending large-scale studies.

Structured PICO

Is ACE2 gene variation associated with cardiovascular disease?

Population

Patients with cardiovascular disease, including hypertension, left ventricular hypertrophy, and coronary artery disease

Intervention

ACE2 gene variation and polymorphisms

Outcome

Cardiovascular disease continuum and circulating ACE2 activity

This review highlights the potential role of the ACE2 gene in cardiovascular disease while emphasizing the need for larger, more rigorous studies to clarify inconsistent genetic associations.

Limitations

Inconsistent results in existing studies
Discrepancies may reflect sample size, gender, ethnicity, cardiovascular phenotype, or the specific ACE2 SNP investigated
Lack of studies concurrently assessing ACE2 gene polymorphisms and circulating ACE2 activity

Cite This Study

Burrell et al. (2012) studied this question.

synapsesocial.com/papers/6a701872fe4101aa97e001d4 https://doi.org/10.1042/cs20120269

View Full Paper

Ask AI

Bookmark

The ACE2 gene: its potential as a functional candidate for cardiovascular disease

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

The ACE2 gene: its potential as a functional candidate for cardiovascular disease

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider