What question did this study set out to answer?

To investigate whether the adipocyte hormone adiponectin mediates the protective actions of dietary saturated fatty acids against alcoholic fatty liver disease.

August 17, 2005HepatologyOpen Access

Role of Adiponectin in the Protective Action of Dietary Saturated Fat Against Alcoholic Fatty Liver in Mice * #

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Authors

MYMin YouQingdao University RCRobert V. ConsidineIndiana University School of Medicine TLTeresa C. LeoneCardiovascular Institute of the South

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Implication

Laboratory study reveals saturated fat stimulates adiponectin to prevent alcoholic fatty liver in mice, suggesting new nutritional strategies for liver disease.

Key Points

To investigate whether the adipocyte hormone adiponectin mediates the protective actions of dietary saturated fatty acids against alcoholic fatty liver disease.
Administered chronic ethanol to mice fed a high-saturated-fat diet to measure circulating adiponectin and evaluate hepatic signaling pathways.
Treated cultured rat 3T3-L1 adipocytes with palmitic or stearic acid in the presence of ethanol to evaluate adiponectin secretion and promoter activity.
Chronic ethanol administration in mice fed saturated fat significantly increased circulating adiponectin concentrations.
Adiponectin elevation was associated with activation of hepatic AMPK, PPAR-alpha, and PGC-1alpha pathways, increasing fatty acid oxidation, preventing hepatic steatosis, and reducing liver enzyme abnormalities.
Treatment of adipocytes with saturated fatty acids during ethanol exposure enhanced mouse adiponectin promoter activity and increased hormone secretion.

Cite This Study

You et al. (2005) studied this question.

synapsesocial.com/papers/6a7018e56c240de38cdbacf6 https://doi.org/10.1002/hep.20821

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Implication

Laboratory study reveals saturated fat stimulates adiponectin to prevent alcoholic fatty liver in mice, suggesting new nutritional strategies for liver disease.

Role of Adiponectin in the Protective Action of Dietary Saturated Fat Against Alcoholic Fatty Liver in Mice * #

Discussion

Member takes

Implication

Key Points

Cite This Study

Role of Adiponectin in the Protective Action of Dietary Saturated Fat Against Alcoholic Fatty Liver in Mice * #

Discussion

Member takes

Implication

Key Points

Cite This Study

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