Congenital Essential Thrombopenic Purpura

TO date, no case of congenital essential thrombopenic purpura in twins has been described in the literature, which contains reports on 19 cases. The literature up to 1936 was reviewed by Sanford, Leslie and Crane,¹who listed 12 cases. Since then cases have been reported by Davidson,²Whitney and Barritt,³Urbanski and Hutner,⁴Schefrin and Schechtman⁵and Morrison and Samwick.⁶The latter proposed the following criteria for a diagnosis of thrombopenic purpura: (1) purpura, with petechiae and ecchymoses; (2) increase in bleeding time; (3) increase in clot retraction time; (4) decrease in platelets; (5) no change in coagulation time; (6) no change in prothrombin time; (7) either normal or increased number of megakaryocytes and/or immature megakaryocytes; (8) normal vitamin C content; (9) positive response to tourniquet test; (10) normal or slightly enlarged spleen; (11) absence of adenopathy; (12) leukemoid reaction with leukocytosis and polynucleosis,