What question did this study set out to answer?

To evaluate the effects of morning methylphenidate hydrochloride administration on sleep patterns and stability in children diagnosed with attention-deficit hyperactivity disorder (ADHD).

December 1, 1993American journal of diseases of children

Effects of Methylphenidate on Sleep in Children With Attention-Deficit Hyperactivity Disorder

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Authors

ETEmanuel TiroshTechnion – Israel Institute of Technology

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Implication

Double-blind crossover trial demonstrates that morning methylphenidate shortens sleep duration in children with ADHD, indicating preserved sleep architecture without adverse effects.

Key Points

To evaluate the effects of morning methylphenidate hydrochloride administration on sleep patterns and stability in children diagnosed with attention-deficit hyperactivity disorder (ADHD).
Conducted a double-blind, controlled drug-placebo crossover study comparing 10 consecutively recruited children with ADHD (aged 6 years 9 months to 12 years) against 20 age- and sex-matched normal controls.
Tracked home activity monitoring across three consecutive phases: 6 days of unmedicated baseline, placebo, and methylphenidate hydrochloride (0.3 to 0.4 mg/kg administered at 7:30 AM).
Total sleep duration was shorter during methylphenidate administration compared with both baseline and placebo conditions.
Quiet sleep was lower (non-significantly) in untreated children with ADHD compared to controls, but this discrepancy was eliminated during methylphenidate treatment.
Night-to-night sleep pattern stability was maintained, with no other significant differences found across treatment phases or between children with ADHD and healthy controls.

Cite This Study

Emanuel Tirosh (1993) studied this question.

synapsesocial.com/papers/6a786377df493903fd1f974a https://doi.org/10.1001/archpedi.1993.02160360055018

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Implication

Double-blind crossover trial demonstrates that morning methylphenidate shortens sleep duration in children with ADHD, indicating preserved sleep architecture without adverse effects.

Effects of Methylphenidate on Sleep in Children With Attention-Deficit Hyperactivity Disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of Methylphenidate on Sleep in Children With Attention-Deficit Hyperactivity Disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

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