What question did this study set out to answer?

To determine whether experimental allergic thyroiditis correlates more closely with circulating anti-thyroid antibody titers or delayed-type hypersensitivity.

April 1, 1961The Journal of Experimental MedicineOpen Access

The Relationship of Delayed Hypersensitivity and Circulating Antibody to Experimental Allergic Thyroiditis in Inbred Guinea Pigs

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Authors

PMPhilip R. B. McMasterNew York State Department of Health ELEdwin M. LernerNational Institutes of Health EEE. D. ExumNational Institutes of Health

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Implication

Experimental study demonstrates a direct correlation between delayed hypersensitivity and allergic thyroiditis in inbred guinea pigs, suggesting cellular immunity drives disease pathology.

Key Points

To determine whether experimental allergic thyroiditis correlates more closely with circulating anti-thyroid antibody titers or delayed-type hypersensitivity.
Immunized histocompatible Strain 13 guinea pigs with thyroid extracts derived either from the same strain or other strains.
Assessed animals for thyroiditis pathology, circulating anti-thyroid antibody titers, and delayed hypersensitivity via skin testing at intervals up to 7 weeks post-immunization.
Allergic thyroiditis emerged as early as 5 days post-immunization and was uniformly present and severe by 7 weeks.
Anti-thyroid antibody titers correlated with disease presence and severity at 7 weeks post-immunization, but failed to correlate consistently at earlier observation points.
Delayed hypersensitivity skin reactions showed a 100% concordance with disease, presenting in every animal with thyroiditis and absent in all unaffected animals.

Cite This Study

McMaster et al. (1961) studied this question.

synapsesocial.com/papers/6a701a63f44fa9f079dda2d2 https://doi.org/10.1084/jem.113.4.611

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Implication

Experimental study demonstrates a direct correlation between delayed hypersensitivity and allergic thyroiditis in inbred guinea pigs, suggesting cellular immunity drives disease pathology.

The Relationship of Delayed Hypersensitivity and Circulating Antibody to Experimental Allergic Thyroiditis in Inbred Guinea Pigs

Discussion

Member takes

Implication

Key Points

Cite This Study

The Relationship of Delayed Hypersensitivity and Circulating Antibody to Experimental Allergic Thyroiditis in Inbred Guinea Pigs

Discussion

Member takes

Implication

Key Points

Cite This Study

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