A PET project: A powerful reagent for the synthesis of positron-emitting imaging molecules—[11C]formaldehyde—is accessible from [11C]methyl iodide and trimethylamine N-oxide (TMAO) in high yields and under mild conditions. Easy access to [11C]formaldehyde expands the scope of the carbon-11 toolbox and will lead to new reaction methodology and imaging compounds.
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Hooker et al. (2008) studied this question.
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