Why the study?
Does a fixed low-dose regimen of warfarin, dipyridamole, and aspirin provide safe anticoagulation without prothrombin time monitoring in patients with St. Jude Medical mechanical valve prostheses?
Population
548 patients with St. Jude Medical mechanical valve prostheses, mean age 32.3 years, 69.7% male.
Design
Cohort
Follow-up
1.1 to 7.2 years
Authors
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May support fixed low-dose regimen without monitoring; hypothesis-generating and requires RCTs before practice change in mechanical valves.
Does a fixed low-dose regimen of warfarin, dipyridamole, and aspirin provide safe anticoagulation without prothrombin time monitoring in patients with St. Jude Medical mechanical valve prostheses?
A fixed daily dose of 2.5 mg warfarin, 225 mg dipyridamole, and 250 mg aspirin without serial prothrombin-time adjustments was reported to provide sufficient anticoagulation for patients with St. Jude Medical mechanical valves.
Yamak et al. (1993) studied this question.
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