What question did this study set out to answer?

To assess whether admission levels of cardiac troponin I can predict clinical severity and mortality in hospitalized patients with COVID-19.

March 23, 2021CureusOpen Access

Cardiac Troponin I Levels in Hospitalized COVID-19 Patients as a Predictor of Severity and Outcome: A Retrospective Cohort Study

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Why the study?

Respiratory manifestations of COVID-19 are common, but myocardial involvement causing myocardial injury and elevation of cardiac markers is much less discussed.

Population

466 hospitalized COVID-19 patients

Comparison

Patients with high cardiac troponin I levels vs those without

Design

Retrospective cohort study

Authors

JAJabar AliLady Reading Hospital FKFahad R KhanLady Reading Hospital RURizwan UllahJinnah Sindh Medical University

Discussion

Member takes

Implication

Elevated troponin signals higher COVID-19 mortality risk; leaves open whether routine testing improves outcomes in prospective studies.

Key Points

To assess whether admission levels of cardiac troponin I can predict clinical severity and mortality in hospitalized patients with COVID-19.
Conducted a retrospective cohort study of hospitalized COVID-19 patients (N=466) between April 1, 2020, and October 1, 2020, extracting data from hospital information systems.
Evaluated patient survival using Kaplan-Meier probability curves, log-rank tests, and Cox proportional hazards regression models.
Myocardial injury was identified in 36.05% (168/466) of patients upon admission, comprising 77.39% (130/168) of nonsurvivors and 22.61% (38/168) of discharged patients.
Elevated admission cardiac troponin I levels were associated with a significantly increased risk of death (hazard ratio [HR] 3.61).

Cite This Study

Ali et al. (2021) studied this question.

synapsesocial.com/papers/6a701cdae71d69abee0860f1 https://doi.org/10.7759/cureus.14061

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Cardiac Troponin I Levels in Hospitalized COVID-19 Patients as a Predictor of Severity and Outcome: A Retrospective Cohort Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Cardiac Troponin I Levels in Hospitalized COVID-19 Patients as a Predictor of Severity and Outcome: A Retrospective Cohort Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider