Why the study?
The relationship between markers of inflammation, hemostasis, and endothelial dysfunction and the clinical manifestations of postthrombotic syndrome in patients with deep vein thrombosis needed investigation.
Are elevated levels of D-dimer, CRP, and homocysteine associated with the development and severity of postthrombotic syndrome in patients with proximal DVT on prolonged anticoagulation?
Are elevated levels of D-dimer, CRP, and homocysteine associated with the development and severity of postthrombotic syndrome in patients with proximal DVT on prolonged anticoagulation?
Elevated biomarkers of inflammation, coagulation, and endothelial dysfunction (CRP, D-dimer, homocysteine) during prolonged anticoagulation for proximal DVT are strong predictors of postthrombotic syndrome development and severity.
Answers are grounded in this paper and cite their sources.
Associations of D-dimer, CRP, and homocysteine with post-thrombotic syndrome severity are hypothesis-generating; prospective studies needed before clinical use.
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Петриков et al. (2020) studied this question.
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