What question did this study set out to answer?

To describe the clinical presentation, neuroimaging findings, and therapeutic management of cerebral toxoplasmosis in a patient with advanced HIV and poor antiretroviral therapy compliance.

September 10, 2025medtigo Journal of MedicineOpen Access

Cerebral Toxoplasmosis in an HIV-Positive 32-Year-Old Male with Poor Antiretroviral Therapy Compliance

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Authors

SASamatha AmpetiOldham Council RMRupashi MukhiaOutcomes Research Consortium PKPatel Nirali KirankumarNarayana Dental College and Hospital

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Implication

Case report reports successful management of cerebral toxoplasmosis in an HIV-positive patient, highlighting the importance of prompt empiric therapy and secondary prophylaxis.

Key Points

To describe the clinical presentation, neuroimaging findings, and therapeutic management of cerebral toxoplasmosis in a patient with advanced HIV and poor antiretroviral therapy compliance.
Evaluated a 32-year-old male with HIV and severe immunosuppression (CD4 count < 100 cells/µL) presenting with fever, seizures, confusion, and focal neurological deficits.
Performed brain magnetic resonance imaging (MRI) revealing multiple ring-enhancing lesions consistent with Toxoplasma gondii reactivation.
Administered acute empiric treatment with pyrimethamine, sulfadiazine, folinic acid, adjunctive corticosteroids, and anticonvulsants, followed by secondary prophylaxis with trimethoprim-sulfamethoxazole and antiretroviral therapy.
Neuroimaging demonstrated multiple characteristic ring-enhancing cerebral lesions associated with profound CD4 T-lymphocyte depletion.
Early empiric antiparasitic therapy combined with seizure management and cerebral edema reduction controlled acute neurological deterioration, enabling safe transition to maintenance prophylaxis and immune restoration.

Cite This Study

Ampeti et al. (2025) studied this question.

synapsesocial.com/papers/6a701d8df44fa9f079dda5f2 https://doi.org/10.63096/medtigo3084237

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Implication

Case report reports successful management of cerebral toxoplasmosis in an HIV-positive patient, highlighting the importance of prompt empiric therapy and secondary prophylaxis.

Cerebral Toxoplasmosis in an HIV-Positive 32-Year-Old Male with Poor Antiretroviral Therapy Compliance

Discussion

Member takes

Implication

Key Points

Cite This Study

Cerebral Toxoplasmosis in an HIV-Positive 32-Year-Old Male with Poor Antiretroviral Therapy Compliance

Discussion

Member takes

Implication

Key Points

Cite This Study

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