Population
Intact muscle (exceptionally well preserved)
Design
Preclinical
Authors
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May inform sarcomere mechanics in animal models; leaves open relevance to human cardiac function and disease.
This study provides the first in vivo structural evidence that MyBP-C bridges thick and thin filaments by binding to actin, revealing a physical mechanism that could modulate muscle contraction.
Luther et al. (2011) studied this question.
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