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January 1, 1999European Heart JournalOpen Access

Frequency and clinical outcome of cardiogenic shock during acute myocardial infarction among patients receiving reteplase or alteplase. Results from GUSTO-III

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Why the study?

Does reteplase reduce 30-day mortality compared to alteplase in patients with acute myocardial infarction complicated by cardiogenic shock?

Population

820 patients with acute myocardial infarction who presented with or developed cardiogenic shock

Comparison

Reteplase (two bolus doses of 10 MU, 30 min apart) vs Front-loaded alteplase

Design

RCT, randomized

Follow-up

30 days

Authors

DHDavid Hasdai

Discussion

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Member takes

Overview

Reteplase confers no mortality benefit over alteplase in AMI shock; confirms similar outcomes and supports either agent.

Structured PICO

Does reteplase reduce 30-day mortality compared to alteplase in patients with acute myocardial infarction complicated by cardiogenic shock?

P
Population
820 patients with acute myocardial infarction who presented with or developed cardiogenic shock (from a total cohort of 15,059 patients in the GUSTO-III trial)
I
Intervention
Reteplase (two bolus doses of 10 MU, 30 min apart)
C
Comparator
Front-loaded alteplase
O
Outcome
30-day mortalityhard clinical

Reteplase does not improve 30-day mortality compared to alteplase in patients with acute myocardial infarction complicated by cardiogenic shock.

Cite This Study

David Hasdai (1999) studied this question.

synapsesocial.com/papers/6a701e89439bab0cabc305ddhttps://doi.org/10.1053/euhj.1999.1282
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Comparison of Reteplase with Alteplase for Acute Myocardial Infarction1997 · 687 citations
  2. 2Platelet Function During and After Thrombolytic Therapy for Acute Myocardial Infarction With Reteplase, Alteplase, or Streptokinase1999 · 70 citations
  3. 3Comparative efficacy of thrombolytics in acute myocardial infarction: a systematic review2003 · 75 citations
  4. 4The role of thrombolytic drugs in the management of myocardial infarction: Comparative clinical trials1996 · 24 citations
  5. 5Survival Outcomes 1 Year After Reperfusion Therapy With Either Alteplase or Reteplase for Acute Myocardial Infarction2000 · 61 citations