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October 10, 2000Circulation

Survival Outcomes 1 Year After Reperfusion Therapy With Either Alteplase or Reteplase for Acute Myocardial Infarction

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Why the study?

Does reteplase improve 1-year survival compared to alteplase in patients with acute myocardial infarction?

Population

15,059 patients with acute myocardial infarction enrolled in the GUSTO-III trial

Comparison

Reteplase (r-PA) vs Alteplase (t-PA)

Design

RCT, random assignment

Follow-up

1 year

Authors

ETEric J. TopolEOE. Magnus OhmanPAPaul W. Armstrong

Discussion

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Overview

Either agent is acceptable for AMI thrombolysis; confirms 1-year equivalence between reteplase and alteplase.

Structured PICO

Does reteplase improve 1-year survival compared to alteplase in patients with acute myocardial infarction?

P
Population
15,059 patients with acute myocardial infarction enrolled in the GUSTO-III trial
I
Intervention
Reteplase (r-PA)
C
Comparator
Alteplase (t-PA)
O
Outcome
Mortality rate at 1 yearhard clinical

Reteplase and alteplase yielded similar 1-year survival outcomes in patients with acute myocardial infarction.

Cite This Study

Topol et al. (2000) studied this question.

synapsesocial.com/papers/6a71079cc1a24a6142dba2f6https://doi.org/10.1161/01.cir.102.15.1761
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Comparison of Reteplase with Alteplase for Acute Myocardial Infarction1997 · 687 citations
  2. 2Recombinant tissue-type plasminogen activator and immediate angioplasty in acute myocardial infarction. One-year follow-up. The European Cooperative Study Group.1992 · 69 citations
  3. 3Streptokinase and Recombinant Tissue Plasminogen Activator (rt-PA) Are Equally Effective in Treating Acute Myocardial Infarction1991 · 58 citations
  4. 4One-Year Results From the Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries (GUSTO-I) Trial1996 · 109 citations
  5. 5More Rapid, Complete, and Stable Coronary Thrombolysis With Bolus Administration of Reteplase Compared With Alteplase Infusion in Acute Myocardial Infarction1995 · 287 citations