Why the study?
Does recombinant tissue-type plasminogen activator (rt-PA) improve mortality or myocardial salvage compared to streptokinase in patients with acute myocardial infarction?
Population
Patients with acute myocardial infarction
Comparison
Recombinant tissue-type plasminogen activator vs Streptokinase
Design
Review
Authors
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rt-PA equals streptokinase for MI mortality and salvage; challenges reliance on 90-minute patency as surrogate endpoint.
Does recombinant tissue-type plasminogen activator (rt-PA) improve mortality or myocardial salvage compared to streptokinase in patients with acute myocardial infarction?
Streptokinase and rt-PA are equally effective for survival after acute myocardial infarction, highlighting the inadequacy of 90-minute patency as a surrogate endpoint for mortality.
Sherry et al. (1991) studied this question.