March 31, 2003Circulation

Noninvasive Assessment of Left Ventricular Force-Frequency Relationships Using Tissue Doppler–Derived Isovolumic Acceleration

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Why the study?

Does tissue Doppler-derived IVA accurately reflect LV contractile function and force-frequency relationships compared to invasive measurements in a porcine model?

Population

12 pigs (6 in study 1, 6 in study 2) in an experimental preparation

Comparison

Measurement of myocardial acceleration during… vs Invasive measurements by conductance…

Design

Preclinical

Authors

MVMichael VogelKarlsruhe Institute of Technology MCMichael M.H. CheungRoyal Children's Hospital JLJia LiRenji Hospital

Discussion

Member takes

Implication

Supports IVA as load-independent LV contractility marker in porcine models; leaves open human translation.

Structured PICO

Does tissue Doppler-derived IVA accurately reflect LV contractile function and force-frequency relationships compared to invasive measurements in a porcine model?

Population

12 pigs (6 in study 1, 6 in study 2) in an experimental preparation

Intervention

Measurement of myocardial acceleration during isovolumic contraction (IVA) using tissue Doppler imaging during contractility modulation (esmolol, dobutamine), preload/afterload changes, and incremental atrial pacing

Comparator

Invasive measurements by conductance catheterization (intraventricular pressure, volume, maximal elastance [Emax], and dP/dtmax)

Outcome

Correlation of IVA with invasive measures of LV contractile function (Emax, dP/dtmax) and response to contractility modulation, preload reduction, afterload increase, and incremental pacingsurrogate

Tissue Doppler-derived IVA provides a noninvasive, load-independent measurement of left ventricular contractile function and force-frequency relationships.

Cite This Study

Vogel et al. (2003) studied this question.

synapsesocial.com/papers/6a701ed3f44fa9f079ddaa17 https://doi.org/10.1161/01.cir.0000058171.62847.90

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Noninvasive Assessment of Left Ventricular Force-Frequency Relationships Using Tissue Doppler–Derived Isovolumic Acceleration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Noninvasive Assessment of Left Ventricular Force-Frequency Relationships Using Tissue Doppler–Derived Isovolumic Acceleration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider