November 1, 1985The Journal of PhysiologyOpen Access

Voltage clamp of bull‐frog cardiac pace‐maker cells: a quantitative analysis of potassium currents.

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Population

Spontaneously active single cells from the sinus venosus region of the bull-frog (Rana catesbeiana)

Design

Preclinical

Authors

WGWayne R. GilesQB3 ESE F ShibataUniversity of Iowa

Discussion

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Implication

Details IK kinetics in amphibian pacemaker cells; leaves open translation to mammalian sinoatrial node function.

Structured PICO

Population

Spontaneously active single cells from the sinus venosus region of the bull-frog (Rana catesbeiana)

Intervention

Voltage-clamp analysis using a single suction micro-electrode technique

Outcome

Transmembrane potassium currents (IK) and their role in pacemaker potential and action potential repolarizationsurrogate

This preclinical study characterizes the kinetics and voltage-dependence of the delayed rectifier potassium current (IK) in bull-frog sinus venosus pacemaker cells.

Cite This Study

Giles et al. (1985) studied this question.

synapsesocial.com/papers/6a701ee55d37378ac1dd2ef5 https://doi.org/10.1113/jphysiol.1985.sp015857

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Voltage clamp of bull‐frog cardiac pace‐maker cells: a quantitative analysis of potassium currents.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Voltage clamp of bull‐frog cardiac pace‐maker cells: a quantitative analysis of potassium currents.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider