Why the study?
Does a quick-clamping method using a PBPK model improve the reliable start time for alcohol clamping compared to an oral/i.v. method in healthy subjects?
Population
20 healthy young subjects (10 males, 10 females)
Comparison
Quick-clamping method using a preprogrammed… vs Oral/i.v. clamping method
Design
Other
Authors
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May accelerate experimental alcohol clamping; leaves open validation and clinical translation beyond healthy subjects.
Does a quick-clamping method using a PBPK model improve the reliable start time for alcohol clamping compared to an oral/i.v. method in healthy subjects?
A PBPK model-based quick-clamping method significantly reduces the delay to achieve a stable breath alcohol concentration compared to oral loading.
Ramchandani et al. (1999) studied this question.
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