An Observational Study for Comparison of Perioperative Effects of Intravenous Clonidine and Dexmedetomidine as Premedication for General Anaesthesia for Thyroidectomy Patients

BACKGROUND system overactivity can result from direct laryngoscopy and in general anaesthesia. This is often associated with tachycardia, , and arrhythmias and can rarely result in ischemia in susceptible . Similar hemodynamic effects can result from surgical stimulation also. plane of anaesthesia, intravenous opioids, beta blockers, lignocaine, , clonidine, alpha blockers, etc. are different techniques used to this. There are many studies comparing various techniques but similar for comparing equal doses (1 mcg/Kg) of intravenous clonidine and are few. obtaining institutional ethical committee clearance, a prospective study among 66 ASA class I and II patients was conducted and among two groups with 33 in each, undergoing thyroidectomy under anaesthesia. Patients were enrolled into two groups. The clonidine group 1 mcg/Kg intravenous clonidine and the dexmedetomidine group 1 /Kg intravenous dexmedetomidine as an infusion over 15 minutes before of general anaesthesia. The hemodynamic response to direct and intubation, surgical incision and extubation as measured by the in heart rate and blood pressure which were monitored in the perioperative . At the end, duration of analgesia defined as the time of start of induction general anaesthesia to the time of first request for rescue analgesic, or VAS (Visual Analogue Scale)= 40 mm were documented. The incidence of side effects, as hypotension, bradycardia, were also monitored. All statistical analyses carried out using the software Statistical Package for the Social Sciences (SPSS) Statistics version 19.0.0 with the help of a professional statistician. Data expressed in its frequency and percentage as well as mean and standard . of the monitored data shows that patients in the dexmedetomidine group more stable hemodynamic effects to direct laryngoscopy, intubation and incision. The duration of analgesia of both the clonidine and were similar and did not show any significant statistical . Both the groups of patients had few cases of side effects like and bradycardia which were neither clinically nor statistically and these were easily remediable. of dexmedetomidine is preferred to clonidine as intravenous premedication at 1 mcg/Kg dose.