November 7, 2024Apollo MedicineOpen Access

There was a statistically significant increase in heart rate and blood pressure in the control group compared to the dexmedetomidine and clonidine groups (P < 0.05), though extubation and orientation times were significantly delayed in the active treatment groups (P < 0.05).

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Why the study?

Laparoscopic surgery causes significant haemodynamic changes from pneumoperitoneum, and α2 adrenergic agonists such as clonidine and dexmedetomidine have been shown to prevent this response.

Does dexmedetomidine or clonidine prevent haemodynamic changes in female patients undergoing laparoscopic hysterectomies?

Population

104 female patients undergoing laparoscopic hysterectomies

Comparison

Dexmedetomidine vs clonidine vs normal saline placebo

Design

Prospective, double-blind, placebo-controlled randomised study

Authors

VSVinit K. Srivastava YKYethirajyam Rama Krishna SKSaima Nouman Khan

Discussion

Member takes

Overview

Both agents blunt hemodynamic surges in laparoscopic hysterectomy; leaves open optimal agent, dosing, and recovery trade-offs.

Structured PICO

Does dexmedetomidine or clonidine prevent haemodynamic changes in female patients undergoing laparoscopic hysterectomies?

Population

104 female patients undergoing laparoscopic hysterectomies

Intervention

Dexmedetomidine (1 μg/kg loading dose over 15 minutes prior to induction, 0.5 μg/kg/h maintenance during surgery) or Clonidine (2 μg/kg loading dose over 15 minutes before induction, 1 μg/kg/h maintenance during surgery)

Comparator

Normal saline (same volume and duration as active treatments)

Outcome

Haemodynamic changes at different time intervalssurrogate

Dexmedetomidine and clonidine effectively attenuate haemodynamic responses during laparoscopic hysterectomies but delay postoperative recovery times.

Cite This Study

Srivastava et al. (2024) studied this question.

synapsesocial.com/papers/6a92894429f7ca37161f5f18 https://doi.org/10.1177/09760016241288302

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November 7, 2024Apollo MedicineOpen Access

There was a statistically significant increase in heart rate and blood pressure in the control group compared to the dexmedetomidine and clonidine groups (P < 0.05), though extubation and orientation times were significantly delayed in the active treatment groups (P < 0.05).

View Full Paper

Ask AI

Bookmark

Why the study?

Laparoscopic surgery causes significant haemodynamic changes from pneumoperitoneum, and α2 adrenergic agonists such as clonidine and dexmedetomidine have been shown to prevent this response.

Does dexmedetomidine or clonidine prevent haemodynamic changes in female patients undergoing laparoscopic hysterectomies?

Population

104 female patients undergoing laparoscopic hysterectomies

Comparison

Dexmedetomidine vs clonidine vs normal saline placebo

Design

Prospective, double-blind, placebo-controlled randomised study

Authors

VSVinit K. Srivastava YKYethirajyam Rama Krishna SKSaima Nouman Khan

Discussion

Member takes

Overview

Both agents blunt hemodynamic surges in laparoscopic hysterectomy; leaves open optimal agent, dosing, and recovery trade-offs.

Structured PICO

Does dexmedetomidine or clonidine prevent haemodynamic changes in female patients undergoing laparoscopic hysterectomies?

Population

104 female patients undergoing laparoscopic hysterectomies

Intervention

Comparator

Normal saline (same volume and duration as active treatments)

Outcome

Haemodynamic changes at different time intervalssurrogate

Dexmedetomidine and clonidine effectively attenuate haemodynamic responses during laparoscopic hysterectomies but delay postoperative recovery times.

Cite This Study

Srivastava et al. (2024) studied this question.

synapsesocial.com/papers/6a92894429f7ca37161f5f18 https://doi.org/10.1177/09760016241288302

View Full Paper

Ask AI

Bookmark