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June 30, 2017Romanian Journal of Medical PracticeOpen Access

Effects of Clonidine versus Midazolam premedication on postoperative pain in patients undergoing elective spinal neurosurgery. Prospective randomized study

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Why the study?

Does clonidine premedication reduce postoperative pain compared to midazolam in patients undergoing elective spinal neurosurgery?

Population

40 ASA physical status I or II patients, aged 18 to 75 years, undergoing elective spinal neurosurgery.

Comparison

Clonidine 0.15 mg orally administered 60-90… vs Midazolam 7.5 mg orally administered 60-90…

Design

RCT, Randomized (details not specified)

Follow-up

24 hours

Authors

ACAna-Maria CotaeCarol Davila University of Medicine and PharmacyLMLiliana MireaCarol Davila University of Medicine and PharmacyRURaluca UngureanuCarol Davila University of Medicine and Pharmacy

Discussion

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Implication

Clonidine premedication lowers postoperative pain and analgesic needs versus midazolam; extends alpha-2 agonist options for elective spinal neurosurgery.

Structured PICO

Does clonidine premedication reduce postoperative pain compared to midazolam in patients undergoing elective spinal neurosurgery?

P
Population
40 ASA physical status I or II patients, aged 18 to 75 years, undergoing elective spinal neurosurgery.
I
Intervention
Clonidine 0.15 mg orally administered 60-90 minutes prior to estimated anaesthesia induction time.
C
Comparator
Midazolam 7.5 mg orally administered 60-90 minutes prior to estimated anaesthesia induction time.
O
Outcome
Severity of postoperative pain assessed immediately after the procedure, 2nd, 6th, 12th and 24th hours after surgery using the visual analog scoring system (VAS score).patient reported

Clonidine premedication significantly reduces the severity of postoperative pain compared to midazolam in patients undergoing elective spinal neurosurgery, without delaying recovery.

Cite This Study

Cotae et al. (2017) studied this question.

synapsesocial.com/papers/6a701f76fe4101aa97e00603https://doi.org/10.37897/rjmp.2017.2.10
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Clonidine on Cardiovascular Morbidity and Mortality after Noncardiac Surgery2004 · 320 citations
  2. 2Effects of Clonidine on Narcotic Requirements and Hemodynamic Response during Induction of Fentanyl Anesthesia and Endotracheal Intubation1986 · 348 citations
  3. 3Pharmacologic and Clinical Aspects of Preoperative Medication1986 · 61 citations
  4. 4Premedication with clonidine is superior to benzodiazepines. A meta analysis of published studies2010 · 151 citations
  5. 5Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children2007 · 152 citations