Why the study?
Are renin-angiotensin system component gene polymorphisms associated with the pathogenesis or severity of bronchial asthma in a Japanese population?
Are renin-angiotensin system component gene polymorphisms associated with the pathogenesis or severity of bronchial asthma in a Japanese population?
Renin-angiotensin system component gene polymorphisms (Agt T235/M235 and ACE I/D) are not associated with the risk or severity of bronchial asthma in the Japanese population.
No association with asthma risk or severity in Japanese patients; leaves open ethnic-specific effects or roles of other variants.
The influence of renin-angiotensin system (RAS) component gene polymorphism in the pathogenesis of bronchial asthma was investigated in an association study involving 119 bronchial asthma patients and 208 control subjects. The selected RAS polymorphisms were angiotensinogen (Agt) T235/M235 and angiotensin I-converting enzyme (ACE) insertion/deletion (I/D). The control allelic frequencies of the Agt T235/M235 (0.84/0.16) and ACE I/D (0.63/0.37) in this study were similar to the previous reports in Japanese normal population. The allelic frequencies of the Agt T235/M235 (0.84/0.16) and ACE I/D (0.65/ 0.35) among the asthma patients were not significantly different from those among the control subjects. There was no association between severity of bronchial asthma and the selected RAS component gene polymorphism. From these data, we conclude that in the Japanese population, the RAS component gene polymorphism is not associated with increased risk for bronchial asthma.
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Nakahama et al. (1999) studied this question.
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