Why the study?
Are renin-angiotensin system component gene polymorphisms associated with end-stage renal disease requiring maintenance haemodialysis in a Japanese population?
Are renin-angiotensin system component gene polymorphisms associated with end-stage renal disease requiring maintenance haemodialysis in a Japanese population?
There is no significant association between RAS component gene polymorphisms (including the ACE D allele) and end-stage renal disease in Japanese patients on maintenance hemodialysis.
Summary: The renin‐angiotension system (RAS) component gene polymorphisms was examined in 216 patients undergoing maintenance haemodialysis (HD) therapy and in 208 control subjects. the RAS polymorphisms selected for analysis were angiotensin I converting enzyme (ACE) I/D, angiotensinogen (Agt) T235/M235, angiotensin II type 1 receptor (AGT1R) A1166/C1166. the control allelic frequencies was ACE I/D (0.63/0.37), Agt T235/M235 (0.16/0.84), and AGT1R A1166/C1166 (0.94/0.06). Recently, relationships between ACE I/D and the progression of renal disease attract great attention in Japanese and Caucasian populations. ACE D allele was expected to be more frequent in HD population. However, no accumulation of ACE D allele or Agt T235 allele, AFT1R C1166 allele in Japanese end‐stage renal disease (ESRD) subjects was detected. to explain the paradoxical result of positive association of ACE D allele with progression of renal disease and no bias of ACE genotype in ESRD subjects, further investigation with systematic prospective study regarding the change of ACE genotype distribution around the period of entering dialysis therapy is required.
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Kawada et al. (1997) studied this question.
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