Why the study?
Does postural change alter cardiovagal modulation in mid stage Huntington's disease patients compared to healthy subjects?
Does postural change alter cardiovagal modulation in mid stage Huntington's disease patients compared to healthy subjects?
Mid stage Huntington's disease patients exhibit reduced cardiovagal modulation upon postural change, which may increase susceptibility to cardiovascular complications such as syncope and arrhythmias.
May signal higher syncope and arrhythmia risk in mid-stage HD; hypothesis-generating and requires prospective validation before clinical adoption.
BACKGROUND: Cardiac autonomic nervous system (ANS) dysfunction in Huntington's disease (HD) might affect both the sympathetic and parasympathetic branch of the ANS. RESULTS AND CONCLUSIONS: The pattern of linear heart rate variability we found in mid stage HD patients points towards a predominately reduced cardiovagal modulation compared with healthy subjects, which might influence HD patients' susceptibility for cardiovascular complications such as syncopes and cardiac arrhythmias.
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Bär et al. (2008) studied this question.
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