Transformation of apparently healthy bovine lymphocytes with phytohemagglutitin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM) from peripheral blood in the perinatal period was observed. In multiparous dairy cows, lymphocyte incorporation of 3H-thymidine (3H-TdR) decreased twice within 40 days after calving: the first one occurred within 10 days, and the second one was seen around 30 days after calving, respectively. This trend of decreasing was almost same in the transformation with PHA, ConA and PWM, respectively. On the other hand, the marked decreasing was seen once around 20 days after parturition in primiparous cows.
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Kashiwazaki et al. (1985) studied this question.