Why the study?
How cortical morphology-function coupling manifests in major depressive disorder and what clinical insights it provides remained unknown.
How does cortical morphology-function coupling differ between patients with major depressive disorder and healthy controls?
Population
830 MDD patients and 853 HC
Comparison
MDD patients vs HC
Design
Cohort study
Authors
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MFC changes in MDD may track symptoms; leaves open diagnostic or therapeutic utility pending validation.
How does cortical morphology-function coupling differ between patients with major depressive disorder and healthy controls?
Patients with major depressive disorder exhibit altered cortical morphology-function coupling in specific brain networks, which correlates with the severity of depressive symptoms.
Wang et al. (2025) studied this question.
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