The preparation of 1,2,4‐thiadiazoles with a di‐ tert ‐butylphenol substituent at the thiadiazole 3‐position is described. A thermally generated nitrile sulfide was reacted with tosyl cyanide in a 1,3‐dipolar cyclization reaction to provide a thiadiazole intermediate containing a labile 5‐tosyl substituent.
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Unangst et al. (1993) studied this question.
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