Cryptococcosis in Solid Organ Transplantation

Cryptococcosis is the third most commonly occurring invasive fungal infection in solid organ transplant (SOT) recipients. Approximately 8% of invasive fungal infections in SOT recipients are due to cryptococcosis (1). The overall incidence of cryptococcosis in SOT recipients ranges from 0.2% to 5% (1,2). Cryptococcosis is typically a late-occurring infection; the median time to onset usually ranges from 16 to 21 months posttransplantation (1,3,4). The time to onset is earlier for liver and lung (<12 months) compared to kidney transplant recipients and this may be due to a higher intensity of immunosuppression in the former subgroups (4).