A hysteresis switch approach for dual-hormone artificial pancreas control offers greater design flexibility and simpler prevention of simultaneous insulin and glucagon injections compared to a MISO formulation.
Answers are grounded in this paper and cite their sources.
Simulation supports hysteresis MPC switching in dual-hormone AP; leaves open clinical efficacy and safety.
In this paper, we evaluate the closed-loop performance of two switching strategies for a dual-hormone artificial pancreas (AP). The dual-hormone AP administers insulin and glucagon subcutaneously. Since insulin and glucagon have opposite effects, we want to avoid simultaneous injections of these two hormones. To handle non-simultaneous injections of insulin and glucagon, we compare model predictive control (MPC) algorithms using a hysteresis switch between insulin and glucagon controllers with a multiple-input single-output (MISO) formulation. Although the closed-loop performance of these two control strategies is similar, the hysteresis switch is preferable due to (i) its greater flexibility in control design and tuning and (ii) a more straightforward way to avoid simultaneous injections of insulin and glucagon.
No takes yet. Share an insight, caveat, or question.
Boiroux et al. (2018) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: