Previous studies on isolated salivary glands of Calliphora have concentrated on the role of cyclic AMP and calcium in mediating the action of 5-hydroxytryptamine (5-HT) (Berridge, 1970; Berridge & Prince, 1972a, b; Prince & Berridge, 1972, 1973; Prince, Berridge & Rasmussen, 1972). Electrophysiological studies suggested that cyclic AMP stimulated a cation pump whereas calcium increased anion permeability. The role of calcium in altering membrane permeability has been confirmed by measuring the resistance of both the apical and basal membranes during the action of 5-HT (Berridge, Lindley & Prince, 1975 a). These resistance measurements have been used to develop a model which adequately accounts for all the potential changes normally observed during the action of 5-HT. The basis of this model depends on having an active pump on the apical membrane which transports potassium from the cell into the lumen. Chloride follows passively. Potassium and chloride transported from the cell into the lumen is replaced by a passive influx of these ions across the basal plasma membrane into the cell.
No takes yet. Share an insight, caveat, or question.
Berridge et al. (1976) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: