What question did this study set out to answer?

To characterize the clinical presentation, longitudinal progression, and neuropathological features of Alzheimer's disease in individuals with Down syndrome aged over 40 years.

July 1, 1985NeurologyOpen Access

Alzheimer's disease in Down's syndrome

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Authors

KWK. E. WisniewskiMedical University of Białystok ADArthur J. DaltonWilliam Harvey Hospital DMD. R. Crapper McLachlanUniversity of Pisa

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Implication

Longitudinal clinicopathologic study reveals progressive neurodegeneration in older adults with Down syndrome, highlighting distinct neuropathologic hallmarks of Alzheimer's disease.

Key Points

To characterize the clinical presentation, longitudinal progression, and neuropathological features of Alzheimer's disease in individuals with Down syndrome aged over 40 years.
Longitudinal clinical and neuropsychological evaluation of N=7 patients with Down syndrome over follow-up periods ranging from 2.5 to 9.2 years.
Postmortem morphometric analysis of brains assessing senile plaque and neurofibrillary tangle density across prefrontal, hippocampal, and subcortical regions.
Clinical progression began with visual memory loss, advanced to impaired learning and social functioning, and culminated in late-stage seizures and urinary incontinence.
All 7 brains exhibited plaque and tangle counts exceeding 20 per 1.5 × 10^6 μm^2 in prefrontal and hippocampal cortices, with involvement extending to the basal ganglia, thalamus, hypothalamus, and midbrain.
Cerebrovascular pathology was prevalent, with amyloid angiopathy identified in 5 of 7 brains and small strokes observed in 4 of 7 brains.

Cite This Study

Wisniewski et al. (1985) studied this question.

synapsesocial.com/papers/6a7026aa75498292b70988d3 https://doi.org/10.1212/wnl.35.7.957

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Implication

Longitudinal clinicopathologic study reveals progressive neurodegeneration in older adults with Down syndrome, highlighting distinct neuropathologic hallmarks of Alzheimer's disease.

Alzheimer's disease in Down's syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

Alzheimer's disease in Down's syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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