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The chemical modification of saturated steroid side chains usually requires a multistep synthesis to construct new side chains to be added to the steroid nucleus.We have found that chromal acetates can be used to directly introduce functionality onto the steroid side chain to produce useful products.These initial products may also provide an entry towards the further modification of the side chain to provide steroids which could previously be obtained only with great difficulty.
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McKee et al. (2015) studied this question.
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