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September 27, 2002Organic Letters110 citations

Simple Synthesis of α-Hydroxyamino Carbonyl Compounds:  New Scope of the Nitroso Aldol Reaction

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NMNorie MomiyamaHYHisashi Yamamoto

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Abstract

reaction: see text The reaction of nitroso compounds with enolates, "the nitroso aldol reaction", occurs in high yield to generate alpha-hydroxyamino carbonyl compounds. Yields range from 42% to 98% with N-selectivity >99:1 from commercially available aromatic or aliphatic nitroso compounds and a variety of alkali metal or tin enolates.

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Momiyama et al. (2002) studied this question.

synapsesocial.com/papers/6a702706b27f15817827386fhttps://doi.org/10.1021/ol026443k
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