November 22, 2022Frontiers in MedicineOpen Access

Lower insulin level is associated with sarcopenia in community-dwelling frail and non-frail older adults

View Full Paper

Ask AI

Bookmark

Why the study?

Evidence regarding the role of insulin in the development of age-related and type 2 diabetes mellitus-related sarcopenia has been conflicting.

Is lower fasting insulin associated with sarcopenia in older adults?

Structured PICO

Is lower fasting insulin associated with sarcopenia in older adults?

Population

246 pre-frail/frail older individuals with (n = 41) and without T2DM (n = 205) in the Singapore Frailty Interventional Trial, and a validation cohort of 189 robust and pre-frail/frail elderly in the Singapore Longitudinal Aging Study Wave 2 (SLAS-2).

Outcome

Presence of sarcopenia (defined by low appendicular lean mass relative to total body mass and low lower limb strength or gait speed according to the Asian Working Group for Sarcopenia criteria)surrogate

Lower fasting insulin levels are independently associated with sarcopenia in both diabetic and non-diabetic older adults, suggesting a role for dysregulated insulin secretion in age-related muscle loss.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports insulin assessment in sarcopenia evaluation; leaves open causal role and intervention potential in older adults.

Cite This Study

Lu et al. (2022) studied this question.

synapsesocial.com/papers/6a70277d87f92105712780dd https://doi.org/10.3389/fmed.2022.971622

View Full Paper

Ask AI

Bookmark

Lower insulin level is associated with sarcopenia in community-dwelling frail and non-frail older adults

Structured PICO

Discussion

Implication

Cite This Study

Lower insulin level is associated with sarcopenia in community-dwelling frail and non-frail older adults

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider