November 24, 2010Thrombosis and Haemostasis
Clopidogrel withdrawal: Is there a “rebound” phenomenon?
Why the study?
Does clopidogrel withdrawal cause a rebound prothrombotic and/or proinflammatory response leading to adverse clinical events in patients with acute coronary syndromes or following percutaneous coronary intervention?
Population
Patients with acute coronary syndromes and following percutaneous coronary intervention
Design
Review
Authors
Discussion
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Member takes
Implication
May warrant caution with abrupt clopidogrel cessation post-ACS/PCI; leaves open whether rebound drives events or tapering mitigates risk.
Structured PICO
Does clopidogrel withdrawal cause a rebound prothrombotic and/or proinflammatory response leading to adverse clinical events in patients with acute coronary syndromes or following percutaneous coronary intervention?
P
Population
Patients with acute coronary syndromes and following percutaneous coronary intervention
I
Intervention
Clopidogrel withdrawal/cessation
This review highlights the potential for a prothrombotic and proinflammatory 'rebound' phenomenon following clopidogrel cessation, which may explain the clustering of adverse clinical events observed in some patients.
Cite This Study
Sambu et al. (2010) studied this question.