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October 1, 1990Annual Review of Physiology

Flash Photolysis Studies of Excitation-Contraction Coupling, Regulation, and Contraction in Smooth Muscle

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Population

Smooth muscle

Design

Review

Authors

ASA P SomlyoASAvril V. Somlyo

Discussion

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Overview

Does not alter vasomotor therapies; leaves open whether phospholipase C or myosin phosphorylation pathways are viable targets.

Structured PICO

P
Population
Smooth muscle
I
Intervention
Flash photolysis of caged compounds (phenylephrine, inositol 1, 4, 5 trisphosphate [InsP3], GTP gamma S, ATP, and CTP)
O
Outcome
Kinetics of excitation-contraction coupling, contractile regulation, and contraction

Flash photolysis of caged compounds reveals that the delay in smooth muscle contraction following agonist stimulation is primarily driven by phospholipase C activation and InsP3 production, with force development limited by myosin light chain phosphorylation.

Cite This Study

Somlyo et al. (1990) studied this question.

synapsesocial.com/papers/6a7027f653da1ffdb5079d70https://doi.org/10.1146/annurev.ph.52.030190.004233
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Also Consider

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  1. 1Cross-bridge phosphorylation and regulation of latch state in smooth muscle1988 · 441 citations
  2. 2Phosphorylation-dependent activated tension in skinned gizzard muscle fibers in the absence of Ca2+.1982 · 91 citations
  3. 3Muscle Contraction and Free Energy Transduction in Biological Systems1985 · 451 citations
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  5. 5Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium.1988 · 355 citations