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October 1, 1988AJP Cell Physiology

Dependence of stress on length, Ca2+, and myosin phosphorylation in skinned smooth muscle

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Population

Detergent skinned tissues of swine carotid media

Comparison

Contraction with various [Ca2+] or initial… vs Comparisons across different tissue lengths and…

Design

Preclinical

Authors

RMR. S. MorelandUniversity of VermontSMSuzanne MorelandBristol-Myers Squibb (United States)RMRichard A. MurphyUniversity of Southern California

Discussion

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Overview

May alter force-maintenance models in stretched vascular preparations; leaves open in vivo relevance of length-dependent crossbridge regulation.

Structured PICO

P
Population
Detergent skinned tissues of swine carotid media
I
Intervention
Contraction with various [Ca2+] or initial contraction with 7-10 microM Ca2+ followed by exposure to a lower [Ca2+], tested at three tissue lengths (0.7, 1.0, and 1.4 times the optimum length for force development [Lo])
C
Comparator
Comparisons across different tissue lengths (0.7, 1.0, and 1.4 Lo) and Ca2+ concentrations
O
Outcome
Isometric force (developed stress) and myosin light chain (MLC) phosphorylation levelssurrogate

In skinned vascular smooth muscle, stress maintenance by dephosphorylated crossbridges is abolished at extended tissue lengths (1.4 Lo), altering the active stress-MLC phosphorylation relationship.

Cite This Study

Moreland et al. (1988) studied this question.

synapsesocial.com/papers/6a8c2676bb5c03e832c461dfhttps://doi.org/10.1152/ajpcell.1988.255.4.c473
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Determinants of Ca2+-dependent stress maintenance in skinned swine carotid media1986 · 32 citations
  2. 2Role of Ca2+ and myosin light chain phosphorylation in regulation of smooth muscle1982 · 170 citations
  3. 3Calcium-Dependent Stress Maintenance Without Myosin Phosphorylation in Skinned Smooth Muscle1983 · 147 citations
  4. 4Dependence of stress on cross-bridge phosphorylation in vascular smooth muscle1989 · 56 citations
  5. 5Effect of Mg<sup>2+</sup>on stress, myosin phosphorylation, and ATPase activity in detergent-skinned swine carotid media1999 · 1 citations