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January 1, 1989AJP Cell Physiology

Dependence of stress on cross-bridge phosphorylation in vascular smooth muscle

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Why the study?

Is cross-bridge phosphorylation necessary and sufficient for activation and maintenance of steady-state stress in vascular smooth muscle?

Population

Swine carotid media

Comparison

Activation using agents that bypass receptor… vs Receptor-mediated activation

Design

Preclinical

Authors

PRPaul H. RatzVirginia Commonwealth UniversityCHChi-Ming HaiBrown UniversityRMRichard A. MurphyUniversity of Southern California

Discussion

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Implication

Should not change clinical management of vascular tone; leaves open translation of Mp thresholds to human disease.

Structured PICO

Is cross-bridge phosphorylation necessary and sufficient for activation and maintenance of steady-state stress in vascular smooth muscle?

P
Population
Swine carotid media
I
Intervention
Activation using agents that bypass receptor activation and elevate Ca2+ influx without mobilizing intracellular Ca2+ stores (BAY K 8644 and ionomycin)
C
Comparator
Receptor-mediated activation
O
Outcome
Dependence of steady-state stress on cross-bridge phosphorylation (Mp)surrogate

This preclinical study demonstrates that calcium-stimulated cross-bridge phosphorylation is obligatory for cross-bridge attachment and steady-state stress maintenance in vascular smooth muscle.

Cite This Study

Ratz et al. (1989) studied this question.

synapsesocial.com/papers/6a71a8d8b27f15817827d1bfhttps://doi.org/10.1152/ajpcell.1989.256.1.c96
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Maximal rates of activation in electrically stimulated swine carotid media.1987 · 39 citations
  2. 2Myosin Phosphorylation and the Cross-Bridge Cycle in Arterial Smooth Muscle1981 · 708 citations
  3. 3Protein kinase C in the regulation of smooth muscle contraction1987 · 549 citations
  4. 4The Function of Myosin and Myosin Light Chain Kinase Phosphorylation in Smooth Muscle1985 · 1,061 citations
  5. 5Length-Tension Relationship of Smooth Muscle of the Hog Carotid Artery1973 · 311 citations