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July 29, 1983Science

Calcium-Dependent Stress Maintenance Without Myosin Phosphorylation in Skinned Smooth Muscle

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Population

Arterial smooth muscle preparation (skinned)

Design

Preclinical

Authors

MCMeeta ChatterjeeJadavpur UniversityRMRichard A. MurphyUniversity of Southern California

Discussion

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Overview

Dual Ca-sensitive mechanisms may regulate arterial tone; hypothesis-generating in animals and leaves open human translation or therapeutic relevance.

Structured PICO

P
Population
Arterial smooth muscle preparation (skinned)
I
Intervention
Controlled calcium concentration
O
Outcome
Stress development and maintenancesurrogate

The study suggests that two regulatory mechanisms with different calcium sensitivities regulate stress and contraction in arterial smooth muscle.

Cite This Study

Chatterjee et al. (1983) studied this question.

synapsesocial.com/papers/6a70b9fa31a3df824328fa48https://doi.org/10.1126/science.6867722
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of Ca2+ and myosin light chain phosphorylation in regulation of smooth muscle1982 · 170 citations
  2. 2Ca2+, cAMP, and changes in myosin phosphorylation during contraction of smooth muscle1983 · 168 citations
  3. 3Myosin light chain phosphorylation associated with contraction in arterial smooth muscle1981 · 243 citations
  4. 4Phosphorylation-dependent activated tension in skinned gizzard muscle fibers in the absence of Ca2+.1982 · 91 citations
  5. 5Myosin Phosphorylation and the Cross-Bridge Cycle in Arterial Smooth Muscle1981 · 708 citations