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May 1, 1999AJP Heart and Circulatory Physiology

Effect of Mg2+on stress, myosin phosphorylation, and ATPase activity in detergent-skinned swine carotid media

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Population

Triton X-100 detergent-skinned fibers of the swine carotid media

Comparison

Increasing Mg2+ concentration in a stepwise… vs Lower Mg2+ concentrations (e.g., 0.1 mM)

Design

Preclinical

Authors

XSXiaoling SuAllegheny CollegeJPJan Willem R. PottUniversity Medical Center GroningenRMRobert S. MorelandBoston University

Discussion

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Implication

Hypothesis-generating in animal vessels; leaves open translation to human vasomotor function or therapy.

Structured PICO

P
Population
Triton X-100 detergent-skinned fibers of the swine carotid media
I
Intervention
Increasing Mg2+ concentration in a stepwise fashion from 0.1 to 6 mM
C
Comparator
Lower Mg2+ concentrations (e.g., 0.1 mM)
O
Outcome
Ca2+-dependent stress development and stress maintenance, myosin ATPase activity, and myosin light chain (MLC) phosphorylation levelssurrogate

Mg2+ differentially modulates MLC phosphorylation-dependent stress development and MLC phosphorylation-independent stress maintenance in vascular smooth muscle.

Cite This Study

Su et al. (1999) studied this question.

synapsesocial.com/papers/6a727147febe604dd70a9ae3https://doi.org/10.1152/ajpheart.1999.276.5.h1416
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dependence of stress on length, Ca2+, and myosin phosphorylation in skinned smooth muscle1988 · 25 citations
  2. 2Calmodulin antagonists inhibit latch bridges in detergent skinned swine carotid media1987 · 28 citations
  3. 3Characteristics of Ca2+- and Mg2+-induced tension development in chemically skinned smooth muscle fibers.1978 · 194 citations
  4. 4Effects of Ca2+ and Mg2+ on the actin-activated ATP hydrolysis by phosphorylated heavy meromyosin from arterial smooth muscle.1984 · 27 citations