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May 1, 1987AJP Cell Physiology

Calmodulin antagonists inhibit latch bridges in detergent skinned swine carotid media

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Population

Detergent skinned swine carotid medial fibers

Comparison

Calmodulin antagonists vs Control conditions

Design

Preclinical

Authors

SMSuzanne MorelandBristol-Myers Squibb (United States)DLDeborah K. LittleRMR. S. MorelandUniversity of Vermont

Discussion

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Implication

No immediate clinical implications from this animal study; leaves open mechanistic roles of calmodulin in smooth muscle stress for further research.

Structured PICO

P
Population
Detergent skinned swine carotid medial fibers
I
Intervention
Calmodulin antagonists (W-7 or trifluoperazine [TFP])
C
Comparator
Control conditions (Ca2+ and ATP or Ca2+ and CTP without antagonists)
O
Outcome
Stress maintenance and myosin light chain (MLC) phosphorylation levelssurrogate

Calmodulin antagonists inhibit both phosphorylation-dependent and independent stress in smooth muscle, suggesting a calmodulin-like Ca2+-binding protein is involved in latch bridge attachment.

Cite This Study

Moreland et al. (1987) studied this question.

synapsesocial.com/papers/6a844146a47fb2e1cdb29eeahttps://doi.org/10.1152/ajpcell.1987.252.5.c523
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of calcium and magnesium on the actomyosin adenosine 5'-triphosphatase of stably phosphorylated gizzard myosin1985 · 42 citations
  2. 2Calcium binding of arterial tropomyosin: involvement in the thin filament regulation of smooth muscle1985 · 8 citations
  3. 3Effect of phosphorylation of smooth muscle myosin on actin activation and Ca2+ regulation.1977 · 305 citations
  4. 4Contraction of detergent-treated smooth muscle.1978 · 80 citations
  5. 5Length-Tension Relationship of Smooth Muscle of the Hog Carotid Artery1973 · 311 citations